All things Chinese CoronaVirus

[wgdsr]

https://www.hospimedica.com/covid-19/ar ... cells.html
https://www.nature.com/articles/s41586-020-2349-y

didn't see this when study came out in may. not sure if someone posted or commented on it.
sounds promising. sars patient from 2003 has antibodies, particularly one of them that may/may not be better in combination with other mAbs from sars, that neutralize the covid 2 virus in vitro and might kick up the immune system as well.
some possible other benefits if true in real life?
- immunity-ish for people who contract covid 2. maybe even long term. this is a stab from an amateur, but at least it sounds reasonable. is S309 or something similar acting in the covid 2 antibody mix?
- vir biotechnology (along with gsk) can evidently turn it around into a therapeutic and maybe vaccine.
- mechanism/timing/target? to neutralize in the disease process also makes it difficult for virus to mutate on it to render the antibody ineffective.
- we have been warned more coronaviruses are coming in the future.

CSO Herbert "Skip" Virgin, M.D., Ph.D., says, “Remarkably, we believe S309 likely covers the entire family of related coronaviruses, which suggests that, even as SARS-CoV-2 continues to evolve, it may be quite challenging for it to become resistant to the neutralizing activity of S309. In addition, S309 exhibits potent effector function in vitro, potentially allowing the antibody to engage and recruit the rest of the immune system to kill off already infected cells. We have seen in animal models of other respiratory infections, such as influenza, that effector function significantly enhances the activity of antibodies that are already potently neutralizing.”

vir also has a recent post up about all that's necessary to get things going on a faster path in a pandemic, posted about this very route in april in nature as well by dr. brian kelley, sr vp of process development and manuf:
https://www.nature.com/articles/s41587-020-0512-5

before i get ahead of myself, yes, it was in the lab. hcq was effective in vitro and of course lots of people have said that doesn't work. however, mAbs- monoclonal antibodies have had the most success vs the very deadly ebola virus, and without trials really being an option. and vir has a big time partner here in gsk. they also work with bill and melinda on something.

Thanks for posting this wgdsr, even for an "amateur"

Let's hope we see a sequel to this in the Good News thread in the not too distant future.

BTW, you probably know more than 90% of CDC and WHO combined...

Now where is Bart, another favorite amateur microbiologist on here, to concur?

well, thanks tech, though i'm not so sure that's such a high bar!

wear a mask, don't wear a mask, this study looks troubling over coffee, cancel everything.
wait... (perusing random dark web email thread).... there's asymptomatic transmission?!?!? are you sure? we're screwed! we've been contaminating our own tests for a month and change with no rush bc this was gonna be easy! - cdc
intl travel from wuhan should be fine, don't worry about those crematoriums.
so months later we now think asymptomatic transmission is very rare... next day -- wait, we misspoke!

we're in great hands.

[wgdsr]

https://www.hospimedica.com/covid-19/ar ... cells.html
https://www.nature.com/articles/s41586-020-2349-y

didn't see this when study came out in may. not sure if someone posted or commented on it.
sounds promising. sars patient from 2003 has antibodies, particularly one of them that may/may not be better in combination with other mAbs from sars, that neutralize the covid 2 virus in vitro and might kick up the immune system as well.
some possible other benefits if true in real life?
- immunity-ish for people who contract covid 2. maybe even long term. this is a stab from an amateur, but at least it sounds reasonable. is S309 or something similar acting in the covid 2 antibody mix?
- vir biotechnology (along with gsk) can evidently turn it around into a therapeutic and maybe vaccine.
- mechanism/timing/target? to neutralize in the disease process also makes it difficult for virus to mutate on it to render the antibody ineffective.
- we have been warned more coronaviruses are coming in the future.

CSO Herbert "Skip" Virgin, M.D., Ph.D., says, “Remarkably, we believe S309 likely covers the entire family of related coronaviruses, which suggests that, even as SARS-CoV-2 continues to evolve, it may be quite challenging for it to become resistant to the neutralizing activity of S309. In addition, S309 exhibits potent effector function in vitro, potentially allowing the antibody to engage and recruit the rest of the immune system to kill off already infected cells. We have seen in animal models of other respiratory infections, such as influenza, that effector function significantly enhances the activity of antibodies that are already potently neutralizing.”

vir also has a recent post up about all that's necessary to get things going on a faster path in a pandemic, posted about this very route in april in nature as well by dr. brian kelley, sr vp of process development and manuf:
https://www.nature.com/articles/s41587-020-0512-5

before i get ahead of myself, yes, it was in the lab. hcq was effective in vitro and of course lots of people have said that doesn't work. however, mAbs- monoclonal antibodies have had the most success vs the very deadly ebola virus, and without trials really being an option. and vir has a big time partner here in gsk. they also work with bill and melinda on something.

Is this just another name for hydroxychloroquine?

hey! it's S309 now. shhh.

[Typical Lax Dad]

https://www.hospimedica.com/covid-19/ar ... cells.html
https://www.nature.com/articles/s41586-020-2349-y

didn't see this when study came out in may. not sure if someone posted or commented on it.
sounds promising. sars patient from 2003 has antibodies, particularly one of them that may/may not be better in combination with other mAbs from sars, that neutralize the covid 2 virus in vitro and might kick up the immune system as well.
some possible other benefits if true in real life?
- immunity-ish for people who contract covid 2. maybe even long term. this is a stab from an amateur, but at least it sounds reasonable. is S309 or something similar acting in the covid 2 antibody mix?
- vir biotechnology (along with gsk) can evidently turn it around into a therapeutic and maybe vaccine.
- mechanism/timing/target? to neutralize in the disease process also makes it difficult for virus to mutate on it to render the antibody ineffective.
- we have been warned more coronaviruses are coming in the future.

CSO Herbert "Skip" Virgin, M.D., Ph.D., says, “Remarkably, we believe S309 likely covers the entire family of related coronaviruses, which suggests that, even as SARS-CoV-2 continues to evolve, it may be quite challenging for it to become resistant to the neutralizing activity of S309. In addition, S309 exhibits potent effector function in vitro, potentially allowing the antibody to engage and recruit the rest of the immune system to kill off already infected cells. We have seen in animal models of other respiratory infections, such as influenza, that effector function significantly enhances the activity of antibodies that are already potently neutralizing.”

vir also has a recent post up about all that's necessary to get things going on a faster path in a pandemic, posted about this very route in april in nature as well by dr. brian kelley, sr vp of process development and manuf:
https://www.nature.com/articles/s41587-020-0512-5

before i get ahead of myself, yes, it was in the lab. hcq was effective in vitro and of course lots of people have said that doesn't work. however, mAbs- monoclonal antibodies have had the most success vs the very deadly ebola virus, and without trials really being an option. and vir has a big time partner here in gsk. they also work with bill and melinda on something.

Is this just another name for hydroxychloroquine?

hey! it's S309 now. shhh.

I am waiting on the guy to call it Hydroxy 309

[6ftstick]

Whoopsie

Dr. Deborah Birx said that recent demonstrations have destroyed a "significant" number of coronavirus testing sites.

On Monday, Birx, the response coordinator for the White House coronavirus task force, told governors on a phone call that protests that erupted into violence following the death of George Floyd led to the destruction of 70 COVID-19 testing sites, making those in inner-city areas more susceptible to having undocumented infections.

"We got a significant number of our testing sites that were serving inner-city groups destroyed at the beginning of the protests. So, there were a lot of pharmacies, and we can see the testing rates in some of the urban areas starting to decline," Birx said in a phone call first obtained by the Daily Beast. "And we did lose a significant — I think 70 testing sites that were in urban areas. So, all of the governors are going to have to scramble to make sure there is testing available in those urban areas," Birx said.

Has this been confirmed by anyone independent of the White House??

My goodness. Why would anyone believe little Debbie? right JHU?

She only drove 328 million people into the corners of their homes cowering from the chinese virus.

why would anyone believe that idiot and not look to you.

[RedFromMI]

A NUMBERS GAME
The Florida COVID-19 data said one thing while Gov. DeSantis sometimes said another

https://www.miamiherald.com/news/politi ... 37591.html

When Gov. Ron DeSantis announced that most of the state would reopen for business on May 4, he cited his administration’s “data-driven strategy” and success at achieving “critical benchmarks in flattening the curve” to contain COVID-19.

But a review of the data the governor was using shows his public pronouncements were often in conflict with real-time facts. He either wasn’t aware the data showed that community spread, regional outbreaks and death tolls were worse than he was telling Floridians, or he selectively focused on outdated statistics to make his case.

A glaring example came on April 29, when the governor brought a slideshow to a news conference to announce that all counties but three in South Florida would lift stay-home orders for many nonessential businesses.

The state had satisfied the “gating criteria,’’ the benchmarks established by the White House Coronavirus Task Force and the Centers for Disease Control and Prevention, to begin the phased reopening of the state, DeSantis said.

“The curve was flattened,’’ he said. “The goal has been satisfied” and “we’ve done much better than everybody said we would do.’’

The curve of new cases had indeed flattened. Both new cases and the percentage of people testing positive for the disease — the “positivity rate” — had been in decline for much of April. But the data suggest that by the time DeSantis announced reopening, those trends were showing signs of reversing.

At the time the governor spoke, the state, excluding South Florida, was on the third day of a four-day rise in the positivity rate, according to confidential Department of Health data obtained exclusively and analyzed by the Miami Herald. New cases were also showing an uptick around that time.

Those increases could have made parts of the state ineligible for reopening for at least 10 more days, depending how the state applied the criteria set by the CDC.

[MDlaxfan76]

Whoopsie

Dr. Deborah Birx said that recent demonstrations have destroyed a "significant" number of coronavirus testing sites.

On Monday, Birx, the response coordinator for the White House coronavirus task force, told governors on a phone call that protests that erupted into violence following the death of George Floyd led to the destruction of 70 COVID-19 testing sites, making those in inner-city areas more susceptible to having undocumented infections.

"We got a significant number of our testing sites that were serving inner-city groups destroyed at the beginning of the protests. So, there were a lot of pharmacies, and we can see the testing rates in some of the urban areas starting to decline," Birx said in a phone call first obtained by the Daily Beast. "And we did lose a significant — I think 70 testing sites that were in urban areas. So, all of the governors are going to have to scramble to make sure there is testing available in those urban areas," Birx said.

Has this been confirmed by anyone independent of the White House??

My goodness. Why would anyone believe little Debbie? right JHU?

She only drove 328 million people into the corners of their homes cowering from the chinese virus.

why would anyone believe that idiot and not look to you.

Is it possible that she was told something untrue?
By others in the White House?
It's not as if she went on a tour of these facilities.

Birx is generally a straight shooter, though she at times tries rather desperately to appease the boss, either by biting her tongue or saying something plausibly consistent with his views.

It would not be a surprise at all if she was fed this.

[MDlaxfan76]

Whoopsie

Dr. Deborah Birx said that recent demonstrations have destroyed a "significant" number of coronavirus testing sites.

On Monday, Birx, the response coordinator for the White House coronavirus task force, told governors on a phone call that protests that erupted into violence following the death of George Floyd led to the destruction of 70 COVID-19 testing sites, making those in inner-city areas more susceptible to having undocumented infections.

"We got a significant number of our testing sites that were serving inner-city groups destroyed at the beginning of the protests. So, there were a lot of pharmacies, and we can see the testing rates in some of the urban areas starting to decline," Birx said in a phone call first obtained by the Daily Beast. "And we did lose a significant — I think 70 testing sites that were in urban areas. So, all of the governors are going to have to scramble to make sure there is testing available in those urban areas," Birx said.

Has this been confirmed by anyone independent of the White House??

WaPo article: https://www.washingtonpost.com/health/s ... story.html

Some fraction is just closures, and some in areas where there are other sites for testing. (Lots of pharmacies like Rite Aid shutting down locations until more settled conditions).

…. temporarily closing is not the same as being "destroyed". Sounds like very few if any actually destroyed.

The business may have been looted, or the building torched, but drive thru testing remains available.

.. if only they had killed some scumbag republicans the day would have been perfect.

Oh so this is an example of the intelligence mdlax was referring to

It was indeed an obnoxious retort to Salty's sarcasm.

Red's (and 72's prior post) was spot on.

[CU77]

Wapo:

Florida got rid of its top geographic data scientist in May. Rebekah Jones now publicizes statistics on her own, at FloridaCOVIDAction.com, which gives a higher case total and a lower number of people tested than data published by the state.

http://FloridaCOVIDAction.com

florida.jpg (33.45 KiB) Viewed 877 times

And more cases coming soon!

EaRbs2cXYAA0M_G-1.jpg (54.51 KiB) Viewed 865 times

MFGA!

AND this just in from the Sunshine State:

Florida recorded more than 1,000 new cases on Tuesday [June 9, after the graph above ends], Wednesday and Thursday, including 1,698 on Thursday, the state’s highest daily total yet. That record only stood for a day: it was eclipsed on Friday, when the state reported another 1,902.

https://www.nytimes.com/2020/06/12/worl ... dates.html

[RedFromMI]

Wearing masks is the most important thing:

(from the Proceedings of the National Academy of Sciences of the Unites States of America)

https://www.pnas.org/content/early/2020 ... 2009637117

Research Article
Identifying airborne transmission as the dominant route for the spread of COVID-19
Renyi Zhang, View ORCID ProfileYixin Li, Annie L. Zhang, View ORCID ProfileYuan Wang, and Mario J. Molina
PNAS first published June 11, 2020 https://doi.org/10.1073/pnas.2009637117

Contributed by Mario J. Molina, May 16, 2020 (sent for review May 14, 2020; reviewed by Manish Shrivastava and Tong Zhu)

Significance

We have elucidated the transmission pathways of coronavirus disease 2019 (COVID-19) by analyzing the trend and mitigation measures in the three epicenters. Our results show that the airborne transmission route is highly virulent and dominant for the spread of COVID-19. The mitigation measures are discernable from the trends of the pandemic. Our analysis reveals that the difference with and without mandated face covering represents the determinant in shaping the trends of the pandemic. This protective measure significantly reduces the number of infections. Other mitigation measures, such as social distancing implemented in the United States, are insufficient by themselves in protecting the public. Our work also highlights the necessity that sound science is essential in decision-making for the current and future public health pandemics.
Abstract

Various mitigation measures have been implemented to fight the coronavirus disease 2019 (COVID-19) pandemic, including widely adopted social distancing and mandated face covering. However, assessing the effectiveness of those intervention practices hinges on the understanding of virus transmission, which remains uncertain. Here we show that airborne transmission is highly virulent and represents the dominant route to spread the disease. By analyzing the trend and mitigation measures in Wuhan, China, Italy, and New York City, from January 23 to May 9, 2020, we illustrate that the impacts of mitigation measures are discernable from the trends of the pandemic. Our analysis reveals that the difference with and without mandated face covering represents the determinant in shaping the pandemic trends in the three epicenters. This protective measure alone significantly reduced the number of infections, that is, by over 78,000 in Italy from April 6 to May 9 and over 66,000 in New York City from April 17 to May 9. Other mitigation measures, such as social distancing implemented in the United States, are insufficient by themselves in protecting the public. We conclude that wearing of face masks in public corresponds to the most effective means to prevent interhuman transmission, and this inexpensive practice, in conjunction with simultaneous social distancing, quarantine, and contact tracing, represents the most likely fighting opportunity to stop the COVID-19 pandemic. Our work also highlights the fact that sound science is essential in decision-making for the current and future public health pandemics.

[old salt]

Wapo:

Florida got rid of its top geographic data scientist in May. Rebekah Jones now publicizes statistics on her own, at FloridaCOVIDAction.com, which gives a higher case total and a lower number of people tested than data published by the state.

http://FloridaCOVIDAction.com


florida.jpg

Florida recorded more than 1,000 new cases on Tuesday [June 9, after the graph above ends], Wednesday and Thursday, including 1,698 on Thursday, the state’s highest daily total yet. That record only stood for a day: it was eclipsed on Friday, when the state reported another 1,902.

https://www.nytimes.com/2020/06/12/worl ... dates.html

Typical NYT/MSM skewed partial reporting. No positivity rate, deaths/day, hospitilizations-acute care-ICU admissions/day

[RedFromMI]

For those of you who have the stomach to click through - the damaged lung of a 20 year old who just got the first pair of transplant lungs due to the covid damage. It is amazing the patient survived until the transplant.

https://twitter.com/tmprowell/status/12 ... 68609?s=21

[CU77]

Wapo:

Florida got rid of its top geographic data scientist in May. Rebekah Jones now publicizes statistics on her own, at FloridaCOVIDAction.com, which gives a higher case total and a lower number of people tested than data published by the state.

http://FloridaCOVIDAction.com


florida.jpg

Florida recorded more than 1,000 new cases on Tuesday [June 9, after the graph above ends], Wednesday and Thursday, including 1,698 on Thursday, the state’s highest daily total yet. That record only stood for a day: it was eclipsed on Friday, when the state reported another 1,902.

https://www.nytimes.com/2020/06/12/worl ... dates.html

Typical NYT/MSM skewed partial reporting. No positivity rate, deaths/day, hospitilizations-acute care-ICU admissions/day

NYT is doing an apples-to-apples comparison. Saying "what about peaches?" changes nothing.

Go to http://FloridaCOVIDAction.com (cited above by me, unmentioned by you) for accurate Florida info.

MFGA!

[Peter Brown]

For those of you who have the stomach to click through - the damaged lung of a 20 year old who just got the first pair of transplant lungs due to the covid damage. It is amazing the patient survived until the transplant.

https://twitter.com/tmprowell/status/12 ... 68609?s=21

The likelihood that this lung story is more complex than ‘young lady with no preconditions sees lungs deteriorate to Black Plague’ is somewhere between 100 and 110%. Count on that.

[tech37]

Whoopsie

Dr. Deborah Birx said that recent demonstrations have destroyed a "significant" number of coronavirus testing sites.

On Monday, Birx, the response coordinator for the White House coronavirus task force, told governors on a phone call that protests that erupted into violence following the death of George Floyd led to the destruction of 70 COVID-19 testing sites, making those in inner-city areas more susceptible to having undocumented infections.

"We got a significant number of our testing sites that were serving inner-city groups destroyed at the beginning of the protests. So, there were a lot of pharmacies, and we can see the testing rates in some of the urban areas starting to decline," Birx said in a phone call first obtained by the Daily Beast. "And we did lose a significant — I think 70 testing sites that were in urban areas. So, all of the governors are going to have to scramble to make sure there is testing available in those urban areas," Birx said.

Has this been confirmed by anyone independent of the White House??

WaPo article: https://www.washingtonpost.com/health/s ... story.html

Some fraction is just closures, and some in areas where there are other sites for testing. (Lots of pharmacies like Rite Aid shutting down locations until more settled conditions).

…. temporarily closing is not the same as being "destroyed". Sounds like very few if any actually destroyed.

The business may have been looted, or the building torched, but drive thru testing remains available.

.. if only they had killed some scumbag republicans the day would have been perfect.

Oh so this is an example of the intelligence mdlax was referring to

It was indeed an obnoxious retort to Salty's sarcasm.

Red's (and 72's prior post) was spot on.

Oh, OS's sarcasm is the problem?

[RedFromMI]

For those of you who have the stomach to click through - the damaged lung of a 20 year old who just got the first pair of transplant lungs due to the covid damage. It is amazing the patient survived until the transplant.

https://twitter.com/tmprowell/status/12 ... 68609?s=21

The likelihood that this lung story is more complex than ‘young lady with no preconditions sees lungs deteriorate to Black Plague’ is somewhere between 100 and 110%. Count on that.

Nope - you are wrong.

From the NYT:

the patient, a woman in her 20s who had no serious underlying medical conditions, was recovering well: “She’s awake, she’s smiling, she FaceTimed with her family.”

[tech37]

Wearing masks is the most important thing:

(from the Proceedings of the National Academy of Sciences of the Unites States of America)

https://www.pnas.org/content/early/2020 ... 2009637117

Research Article
Identifying airborne transmission as the dominant route for the spread of COVID-19
Renyi Zhang, View ORCID ProfileYixin Li, Annie L. Zhang, View ORCID ProfileYuan Wang, and Mario J. Molina
PNAS first published June 11, 2020 https://doi.org/10.1073/pnas.2009637117

Contributed by Mario J. Molina, May 16, 2020 (sent for review May 14, 2020; reviewed by Manish Shrivastava and Tong Zhu)

Significance

We have elucidated the transmission pathways of coronavirus disease 2019 (COVID-19) by analyzing the trend and mitigation measures in the three epicenters. Our results show that the airborne transmission route is highly virulent and dominant for the spread of COVID-19. The mitigation measures are discernable from the trends of the pandemic. Our analysis reveals that the difference with and without mandated face covering represents the determinant in shaping the trends of the pandemic. This protective measure significantly reduces the number of infections. Other mitigation measures, such as social distancing implemented in the United States, are insufficient by themselves in protecting the public. Our work also highlights the necessity that sound science is essential in decision-making for the current and future public health pandemics.
Abstract

Various mitigation measures have been implemented to fight the coronavirus disease 2019 (COVID-19) pandemic, including widely adopted social distancing and mandated face covering. However, assessing the effectiveness of those intervention practices hinges on the understanding of virus transmission, which remains uncertain. Here we show that airborne transmission is highly virulent and represents the dominant route to spread the disease. By analyzing the trend and mitigation measures in Wuhan, China, Italy, and New York City, from January 23 to May 9, 2020, we illustrate that the impacts of mitigation measures are discernable from the trends of the pandemic. Our analysis reveals that the difference with and without mandated face covering represents the determinant in shaping the pandemic trends in the three epicenters. This protective measure alone significantly reduced the number of infections, that is, by over 78,000 in Italy from April 6 to May 9 and over 66,000 in New York City from April 17 to May 9. Other mitigation measures, such as social distancing implemented in the United States, are insufficient by themselves in protecting the public. We conclude that wearing of face masks in public corresponds to the most effective means to prevent interhuman transmission, and this inexpensive practice, in conjunction with simultaneous social distancing, quarantine, and contact tracing, represents the most likely fighting opportunity to stop the COVID-19 pandemic. Our work also highlights the fact that sound science is essential in decision-making for the current and future public health pandemics.

But the WHO said, no need for face masks... what a crock... all around

[tech37]

For those of you who have the stomach to click through - the damaged lung of a 20 year old who just got the first pair of transplant lungs due to the covid damage. It is amazing the patient survived until the transplant.

https://twitter.com/tmprowell/status/12 ... 68609?s=21

The likelihood that this lung story is more complex than ‘young lady with no preconditions sees lungs deteriorate to Black Plague’ is somewhere between 100 and 110%. Count on that.

Nope - you are wrong.

From the NYT:

the patient, a woman in her 20s who had no serious underlying medical conditions, was recovering well: “She’s awake, she’s smiling, she FaceTimed with her family.”

Well Red, if you haven't learned by now to question anything from NYT, I'd say you're gullible.

[RedFromMI]

For those of you who have the stomach to click through - the damaged lung of a 20 year old who just got the first pair of transplant lungs due to the covid damage. It is amazing the patient survived until the transplant.

https://twitter.com/tmprowell/status/12 ... 68609?s=21

The likelihood that this lung story is more complex than ‘young lady with no preconditions sees lungs deteriorate to Black Plague’ is somewhere between 100 and 110%. Count on that.

Nope - you are wrong.

From the NYT:

the patient, a woman in her 20s who had no serious underlying medical conditions, was recovering well: “She’s awake, she’s smiling, she FaceTimed with her family.”

Well Red, if you haven't learned by now to question anything from NYT, I'd say you're gullible.

On a factual story there is little likelihood of an error. You are making a mistake if you think they are often in error on something like this.

From npr:

Doctors at Northwestern Memorial Hospital in Chicago announced Thursday they've performed the first successful double-lung transplant on a COVID-19 patient in the United States.

The woman in her 20s was otherwise healthy but developed a severe case of COVID-19 that resulted in hospitalization, says Dr. Ankit Bharat, Northwestern's chief of thoracic surgery.

You could be checking other sources if you wanted to.

[Peter Brown]

For those of you who have the stomach to click through - the damaged lung of a 20 year old who just got the first pair of transplant lungs due to the covid damage. It is amazing the patient survived until the transplant.

https://twitter.com/tmprowell/status/12 ... 68609?s=21

The likelihood that this lung story is more complex than ‘young lady with no preconditions sees lungs deteriorate to Black Plague’ is somewhere between 100 and 110%. Count on that.

Nope - you are wrong.

From the NYT:

the patient, a woman in her 20s who had no serious underlying medical conditions, was recovering well: “She’s awake, she’s smiling, she FaceTimed with her family.”

Wow if it’s from the NYT, it’s got to be true! What was I thinking!

[RedFromMI]

Information directly from the head of thoracic surgery at NW where they did the procedure. I guess you did not bother to check yourself and see others have the same story. (Or my alternate reference).

Typical PB - lightweight who is trolling, nothing real to add.