On Friday, all the favored teams won.
| 1 | Cardinal Gibbons | #1 | 15 – 8 | #8 | Wilmington Hoggard | 05/13/2022 |
| 2 | Charlotte CDS | #17 | 10 – 3 | #30 | Durham Academy | 05/13/2022 |
| 3 | Lake Norman Charter | #24 | 16 – 12 | #32 | Christ The King | 05/13/2022 |
| 4 | Providence Day | #14 | 8 – 2 | #43 | Ravenscroft School | 05/13/2022 |
| 5 | Christ School | #5 | 17 – 10 | #53 | Cary Academy | 05/13/2022 |
| 6 | Cannon School | #4 | 17 – 5 | #54 | Greensboro Day | 05/13/2022 |
| 7 | First Flight | #28 | 12 – 6 | #51 | Croatan | 05/13/2022 |
| 8 | Cape Fear Academy | #39 | 15 – 0 | #109 | Arendell Parrott Academy | 05/13/2022 |
| 9 | Asheville School | #64 | 13 – 9 | #99 | St Davids School | 05/13/2022 |
| 10 | Southlake Christian | #44 | 20 – 1 | #120 | Cary Christian | 05/13/2022 |
These are tomorrow’s Best Games:
| 1 | Middle Creek | #3 | vs | #1 | Cardinal Gibbons | 05/17/2022 |
| 2 | Hough | #6 | vs | #12 | Weddington | 05/17/2022 |
| 3 | Providence Day | #14 | vs | #5 | Christ School | 05/17/2022 |
| 4 | Charlotte CDS | #17 | vs | #4 | Cannon School | 05/17/2022 |
| 5 | Lake Norman Charter | #24 | vs | #36 | Bishop McGuinness | 05/17/2022 |
| 6 | First Flight | #28 | vs | #33 | Hillsborough Orange | 05/17/2022 |
| 7 | Southlake Christian | #44 | vs | #39 | Cape Fear Academy | 05/17/2022 |
| 8 | Asheville School | #64 | vs | #37 | Forsyth Country Day | 05/17/2022 |
