These are this weekend’s Best National Tournament Games in order:
| 1 | Salisbury | #1 | vs | #22 | Stockton | 05/14/2022 |
| 2 | MIT | #12 | vs | #15 | Amherst | 05/14/2022 |
| 3 | Union | #2 | vs | #28 | John Carroll | 05/14/2022 |
| 4 | Wesleyan | #21 | vs | #13 | RPI | 05/14/2022 |
| 5 | Saint John Fisher | #6 | vs | #29 | Catholic | 05/14/2022 |
| 6 | Dickinson | #5 | vs | #33 | Stevens | 05/14/2022 |
| 7 | St. Lawrence | #8 | vs | #31 | Cortland | 05/14/2022 |
| 8 | Gettysburg | #17 | vs | #27 | Roanoke | 05/14/2022 |
| 9 | Washington and Lee | #25 | vs | #23 | Cabrini | 05/14/2022 |
| 10 | Lynchburg | #11 | vs | #42 | Western New England | 05/14/2022 |
| 11 | Bowdoin | #7 | vs | #51 | Colorado College | 05/14/2022 |
| 12 | Stevens | #33 | vs | #29 | Catholic | 05/15/2022 |
| 13 | Denison | #24 | vs | #40 | Grove City | 05/13/2022 |
| 14 | York | #9 | vs | #57 | Southern Virginia | 05/13/2022 |
| 15 | RIT | #3 | vs | #67 | Albion | 05/14/2022 |
| 16 | Tufts | #10 | vs | #85 | Norwich | 05/14/2022 |
| 17 | Christopher Newport | #4 | vs | #92 | Sewanee | 05/14/2022 |
