Best Upsets are marked with an asterisks*. Some teams (e.g. Notre Dame and a couple of B1G teams) are under-rated due to having limited quality wins.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Syracuse | #4 | 13 – 11 | #5 | Virginia | 04/24/2021 |
| 2 | North Carolina | #2 | 12 – 10 | #9 | Notre Dame | 04/25/2021 |
| 3* | Navy | #11 | 9 – 4 | #10 | Army | 04/24/2021 |
| 4* | Delaware | #16 | 16 – 8 | #14 | Towson | 04/24/2021 |
| 5 | Maryland | #3 | 14 – 13 | #30 | Johns Hopkins | 04/24/2021 |
| 6 | Drexel | #12 | 12 – 8 | #28 | Hofstra | 04/24/2021 |
| 7 | Penn State | #17 | 10 – 9 | #25 | Ohio State | 04/24/2021 |
| 8 | Rutgers | #8 | 13 – 12 | #35 | Michigan | 04/25/2021 |
| 9 | Georgetown | #7 | 14 – 5 | #39 | Providence | 04/24/2021 |
| 10 | Villanova | #20 | 19 – 8 | #34 | Marquette | 04/24/2021 |
| 11 | Richmond | #18 | 21 – 8 | #43 | Mercer | 04/25/2021 |
| 12 | Lehigh | #6 | 18 – 12 | #56 | Bucknell | 04/24/2021 |
| 13 | Denver | #13 | 19 – 11 | #50 | St. John’s | 04/24/2021 |
| 14 | UMass | #22 | 21 – 14 | #47 | Fairfield | 04/24/2021 |
| 15 | High Point | #26 | 13 – 8 | #45 | Air Force | 04/24/2021 |
| 16 | Binghamton | #33 | 10 – 7 | #38 | Vermont | 04/24/2021 |
| 17 | Saint Joseph’s | #27 | 14 – 13 | #46 | LIU | 04/24/2021 |
| 18 | UAlbany | #15 | 18 – 8 | #61 | NJIT | 04/24/2021 |
| 19 | Hobart | #37 | 14 – 10 | #40 | Merrimack | 04/24/2021 |
| 20 | Holy Cross | #36 | 12 – 5 | #44 | Boston University | 04/23/2021 |
| 21 | Loyola | #21 | 11 – 7 | #62 | Lafayette | 04/24/2021 |
| 22 | Marist | #32 | 14 – 7 | #51 | Manhattan | 04/24/2021 |
| 23 | Jacksonville | #31 | 8 – 7 | #54 | Bellarmine | 04/24/2021 |
| 24 | Bryant | #29 | 20 – 12 | #66 | Sacred Heart | 04/24/2021 |
| 25 | Utah | #42 | 11 – 9 | #57 | Cleveland State | 04/24/2021 |
