Numerous Best Games this weekend (below) and 0 Upsets.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | North Carolina | #2 | 21 – 9 | #9 | Syracuse | 04/17/2021 |
| 2 | Georgetown | #6 | 11 – 10 | #11 | Denver | 04/17/2021 |
| 3 | Maryland | #3 | 18 – 8 | #18 | Ohio State | 04/18/2021 |
| 4 | Navy | #13 | 14 – 12 | #22 | Loyola | 04/17/2021 |
| 5 | Towson | #12 | 9 – 6 | #23 | UMass | 04/17/2021 |
| 6 | Rutgers | #7 | 17 – 11 | #33 | Johns Hopkins | 04/17/2021 |
| 7 | Army | #8 | 14 – 8 | #35 | Boston University | 04/17/2021 |
| 8 | Delaware | #16 | 14 – 13 | #28 | Hofstra | 04/17/2021 |
| 9 | Virginia | #4 | 18 – 11 | #44 | Utah | 04/17/2021 |
| 10 | Richmond | #17 | 14 – 7 | #34 | Jacksonville | 04/17/2021 |
| 11 | Saint Joseph’s | #26 | 13 – 5 | #30 | Bryant | 04/17/2021 |
| 12 | Penn State | #21 | 14 – 13 | #36 | Michigan | 04/16/2021 |
| 13 | Drexel | #14 | 19 – 7 | #49 | Fairfield | 04/17/2021 |
| 14 | Stony Brook | #19 | 22 – 8 | #45 | Binghamton | 04/16/2021 |
| 15 | Lehigh | #5 | 14 – 11 | #61 | Lafayette | 04/18/2021 |
| 16 | Lehigh | #5 | 18 – 11 | #61 | Lafayette | 04/16/2021 |
| 17 | High Point | #27 | 16 – 10 | #42 | Mercer | 04/17/2021 |
| 18 | Marquette | #32 | 7 – 6 | #38 | Providence | 04/17/2021 |
| 19 | Villanova | #20 | 23 – 8 | #51 | St. John’s | 04/17/2021 |
| 20 | Robert Morris | #24 | 8 – 7 | #56 | Bucknell | 04/16/2021 |
| 21 | UMBC | #25 | 12 – 7 | #59 | UMass Lowell | 04/17/2021 |
| 22 | LIU | #41 | 17 – 15 | #53 | Mount St Mary’s | 04/17/2021 |
| 23 | Merrimack | #39 | 14 – 10 | #64 | Sacred Heart | 04/17/2021 |
| 24 | Air Force | #46 | 18 – 4 | #58 | VMI | 04/17/2021 |
| 25 | Hartford | #50 | 14 – 9 | #60 | NJIT | 04/17/2021 |
