These (below) were yesterday’s Best HS Girls Games in Florida. There was 1 Upset, which was barely an upset but an upset none the less, and this Upset was also a Best Game which is marked with an asterisk (below).
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Stoneman Douglas (FL) | #10 | 21 – 9 | #17 | Boca Raton (FL) | 04/14/2021 |
| 2 | St. Thomas Aquinas (FL) | #2 | 19 – 3 | #30 | Taravella (FL) | 04/14/2021 |
| 3 | Viera (FL) | #33 | 11 – 8 | #38 | South Fork (FL) | 04/14/2021 |
| 4 | Vero Beach (FL) | #3 | 20 – 1 | #73 | Sebastian River (FL) | 04/14/2021 |
| 5 | Cypress Bay (FL) | #15 | 9 – 7 | #64 | Palmetto (FL) | 04/14/2021 |
| 6* | Naples (FL) | #53 | 18 – 5 | #51 | Barron Collier (FL) | 04/14/2021 |
| 7 | Western (FL) | #16 | 16 – 3 | #94 | Flanagan (FL) | 04/14/2021 |
| 8 | Community School of Naples (FL) | #14 | 19 – 3 | #131 | Lely (FL) | 04/14/2021 |
| 9 | Gulf Breeze (FL) | #25 | 18 – 3 | #124 | Pensacola (FL) | 04/14/2021 |
| 10 | Plant (FL) | #41 | 22 – 6 | #148 | St. Petersburg (FL) | 04/14/2021 |
| 11 | East Lake (FL) | #54 | 12 – 6 | #136 | Sickles (FL) | 04/14/2021 |
