Numerous Best Games this weekend, 5 Upsets, and 5 Best Upsets (marked with an asterisks below).
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Hutchison (TN) | #1 | 11 – 9 | #8 | Ravenwood (TN) | 04/09/2021 |
| 2 | St. Mary’s Episcopal (TN) | #4 | 19 – 12 | #8 | Ravenwood (TN) | 04/10/2021 |
| 3 | Harpeth Hall (TN) | #3 | 17 – 9 | #10 | Briarcrest Christian (TN) | 04/09/2021 |
| 4* | Briarcrest Christian (TN) | #10 | 17 – 6 | #5 | Ensworth (TN) | 04/10/2021 |
| 5 | Collierville (TN) | #7 | 11 – 5 | #19 | Houston (TN) | 04/09/2021 |
| 6 | Ensworth (TN) | #5 | 18 – 3 | #27 | Father Ryan (TN) | 04/09/2021 |
| 7 | White Station (TN) | #15 | 17 – 5 | #40 | Pulaski Academy (TN) | 04/10/2021 |
| 8* | Lausanne Collegiate (TN) | #31 | 6 – 4 | #28 | Bartlett (TN) | 04/10/2021 |
| 9 | White Station (TN) | #15 | 20 – 1 | #46 | Bryant (TN) | 04/10/2021 |
| 10 | Cookeville (TN) | #20 | 23 – 1 | #52 | RCK (CO-OP) (TN) | 04/09/2021 |
