Numerous Best Games this weekend, 1 Upsets, and 1 Best Upsets (marked with an asterisks below).
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Baylor School (TN) | #2 | 16 – 12 | #8 | Montgomery Bell Academy (TN) | 04/10/2021 |
| 2 | Baylor School (TN) | #2 | 19 – 12 | #11 | Father Ryan (TN) | 04/09/2021 |
| 3 | Houston (TN) | #6 | 11 – 7 | #7 | Collierville (TN) | 04/09/2021 |
| 4 | Christian Academy of Knoxville (TN) | #3 | 9 – 7 | #26 | Boyd Buchanan (TN) | 04/10/2021 |
| 5 | Brentwood (TN) | #20 | 18 – 3 | #21 | Knoxville Catholic (TN) | 04/11/2021 |
| 6 | Arlington (TN) | #18 | 9 – 8 | #36 | Clarksville (TN) | 04/10/2021 |
| 7 | Ensworth (TN) | #28 | 13 – 8 | #31 | Evangelical Christian (TN) | 04/10/2021 |
| 8 | St George’s (TN) | #12 | 9 – 6 | #47 | University School of Nashville (TN) | 04/10/2021 |
| 9 | Science Hill (TN) | #32 | 11 – 6 | #37 | Farragut (TN) | 04/10/2021 |
| 10 | Clarksville (TN) | #36 | 13 – 2 | #46 | Bartlett (TN) | 04/09/2021 |
| 11* | Sullivan County (TN) | #44 | 15 – 4 | #41 | Tennessee High School (TN) | 04/09/2021 |
