Numerous Best Games this weekend and 2 Best Upsets (marked with an asterisks below) including Notre Dame beating Duke. Not listed as an upset (below) because it wasn’t a Best Game was #63 St. Bonaventure beating #62 Canisius, 12-11.
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Virginia | #3 | 18 – 16 | #4 | North Carolina | 04/10/2021 |
| 2* | Notre Dame | #7 | 13 – 8 | #1 | Duke | 04/10/2021 |
| 3 | Lehigh | #5 | 13 – 7 | #15 | Navy | 04/10/2021 |
| 4 | Army | #8 | 12 – 7 | #14 | Loyola | 04/10/2021 |
| 5 | Denver | #10 | 17 – 10 | #20 | Villanova | 04/10/2021 |
| 6 | Maryland | #2 | 18 – 12 | #33 | Michigan | 04/10/2021 |
| 7 | UAlbany | #13 | 14 – 9 | #23 | UMBC | 04/11/2021 |
| 8 | Rutgers | #6 | 22 – 10 | #30 | Penn State | 04/10/2021 |
| 9 | Drexel | #12 | 12 – 9 | #25 | Delaware | 04/10/2021 |
| 10 | Hofstra | #19 | 12 – 11 | #21 | UMass | 04/09/2021 |
| 11 | Ohio State | #17 | 14 – 12 | #35 | Johns Hopkins | 04/10/2021 |
| 12 | Georgetown | #11 | 10 – 8 | #46 | Marquette | 04/10/2021 |
| 13 | Saint Joseph’s | #31 | 13 – 12 | #37 | Hobart | 04/10/2021 |
| 14 | Towson | #22 | 12 – 11 | #50 | Fairfield | 04/10/2021 |
| 15 | Stony Brook | #18 | 12 – 8 | #55 | NJIT | 04/10/2021 |
| 16 | Providence | #29 | 19 – 9 | #45 | St. John’s | 04/10/2021 |
| 17 | Boston University | #36 | 14 – 10 | #41 | Colgate | 04/10/2021 |
| 18 | Jacksonville | #32 | 11 – 5 | #47 | Air Force | 04/10/2021 |
| 19 | Robert Morris | #27 | 15 – 7 | #56 | Cleveland State | 04/10/2021 |
| 20 | Vermont | #26 | 16 – 5 | #59 | UMass Lowell | 04/10/2021 |
| 21* | Hartford | #51 | 8 – 7 | #42 | Binghamton | 04/10/2021 |
| 22 | Merrimack | #43 | 12 – 11 | #52 | Mount St Mary’s | 04/10/2021 |
| 23 | Monmouth | #40 | 9 – 7 | #57 | Detroit Mercy | 04/09/2021 |
| 24 | Bucknell | #48 | 14 – 6 | #61 | Lafayette | 04/10/2021 |
| 25 | Bellarmine | #54 | 11 – 9 | #58 | VMI | 04/10/2021 |
