| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Castle (IN) | #6 | vs | #17 | Bishop Chatard (IN) | 04/10/2021 |
| 2 | Evansville North (IN) | #8 | vs | #17 | Bishop Chatard (IN) | 04/10/2021 |
| 3 | Roncalli (IN) | #19 | vs | #11 | Crown Point (IN) | 04/10/2021 |
| 4 | Brownsburg (IN) | #13 | vs | #18 | Homestead (IN) | 04/11/2021 |
| 5 | Munster (IN) | #20 | vs | #13 | Brownsburg (IN) | 04/11/2021 |
| 6 | Park Tudor (IN) | #12 | vs | #25 | Evansville Central (IN) | 04/10/2021 |
| 7 | Munster (IN) | #20 | vs | #18 | Homestead (IN) | 04/11/2021 |
| 8 | Roncalli (IN) | #19 | vs | #21 | Chesterton (IN) | 04/10/2021 |
| 9 | Park Tudor (IN) | #12 | vs | #30 | F. J. Reitz (IN) | 04/10/2021 |
| 10 | Plainfield (IN) | #28 | vs | #21 | Chesterton (IN) | 04/10/2021 |
| 11 | Roncalli (IN) | #19 | vs | #32 | Lawrence North (IN) | 04/10/2021 |
| 12 | Lawrence North (IN) | #32 | vs | #21 | Chesterton (IN) | 04/10/2021 |
| 13 | Bosse (IN) | #29 | vs | #27 | South Gibson (IN) | 04/09/2021 |
| 14 | Avon (IN) | #22 | vs | #36 | Lafayette Harrison (IN) | 04/09/2021 |
| 15 | Bloomington (IN) | #35 | vs | #25 | Evansville Central (IN) | 04/10/2021 |
| 16 | Bloomington (IN) | #35 | vs | #30 | F. J. Reitz (IN) | 04/10/2021 |
