This weekend, there are numerous games and several are quality games. These games, in order, are:
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Bishop England (SC) | #1 | vs | #15 | River Bluff (SC) | 03/20/2021 |
| 2 | Socastee (SC) | #11 | vs | #12 | Wando (SC) | 03/19/2021 |
| 3 | Porter-Gaud (SC) | #22 | vs | #6 | Lucy Beckham (SC) | 03/20/2021 |
| 4 | Philip Simmons (SC) | #37 | vs | #4 | Oceanside Collegiate Academy (SC) | 03/19/2021 |
| 5 | Greenville (SC) | #38 | vs | #7 | Flora (SC) | 03/20/2021 |
| 6 | Byrnes (SC) | #42 | vs | #3 | Spartanburg (SC) | 03/19/2021 |
| 7 | Dorman (SC) | #51 | vs | #5 | Riverside (SC) | 03/19/2021 |
| 8 | South Effingham (SC) | #39 | vs | #46 | May River (SC) | 03/20/2021 |
| 9 | James Island (SC) | #55 | vs | #32 | Pinewood Prep (SC) | 03/20/2021 |
| 10 | Lexington (SC) | #50 | vs | #44 | White Knoll (SC) | 03/19/2021 |
| 11 | T.L. Hanna (SC) | #29 | vs | #0 | Evans (SC) | 03/19/2021 |
