This weekend, there are numerous games and several are quality games. These games, in order, are:
| – | Team | Rank | VS | Rank | Opp Team | Details |
| 1 | Porter-Gaud (SC) | #8 | vs | #6 | Lucy Beckham (SC) | 03/20/2021 |
| 2 | Oceanside Collegiate Academy (SC) | #2 | vs | #13 | Christ Church Episcopal (SC) | 03/19/2021 |
| 3 | Bishop England (SC) | #12 | vs | #4 | Flora (SC) | 03/20/2021 |
| 4 | Mann (SC) | #3 | vs | #20 | Fort Mill (SC) | 03/20/2021 |
| 5 | Wando (SC) | #1 | vs | #28 | James Island (SC) | 03/20/2021 |
| 6 | Riverside (SC) | #23 | vs | #11 | Dorman (SC) | 03/19/2021 |
| 7 | Spartanburg (SC) | #25 | vs | #10 | Byrnes (SC) | 03/19/2021 |
| 8 | Blythewood (SC) | #17 | vs | #19 | Greenville (SC) | 03/19/2021 |
| 9 | Blythewood (SC) | #17 | vs | #41 | Irmo (SC) | 03/19/2021 |
| 10 | T.L. Hanna (SC) | #45 | vs | #33 | River Bluff (SC) | 03/20/2021 |
| 11 | Fox Creek (SC) | #52 | vs | #37 | Wade Hampton (SC) | 03/19/2021 |
