In order, based on the rankings of the two opponents, these were this weekend’s “Best Games” and the game results.
| – | Team | VS | Opp Team |
| 1 | Riverside (SC) | 15 – 7 | Mann (SC) |
| 2 | St. James (SC) | 16 – 3 | Flora (SC) |
| 3 | Bishop England (SC) | 18 – 2 | Clover (SC) |
| 4 | Clover (SC) | 14 – 1 | Boiling Springs (SC) |
| 5 | Spartanburg (SC) | 21 – 0 | Hillcrest (SC) |
| 6 | Oceanside Collegiate Academy (SC) | 18 – 5 | Waccamaw (SC) |
| 7 | Wade Hampton (SC) | 11 – 9 | Dorman (SC) |
| 8 | Dutch Fork (SC) | 15 – 4 | Spring Valley (SC) |
| 9 | Mauldin (SC) | 6 – 5 | T.L. Hanna (SC) |
| 10 | Greenville (SC) | 17 – 5 | Woodmont (SC) |
There was one upset, Peachtree Ridge beat Collins Hill, 19-6. Though, this early in the season, it’s difficult to call this an upset.
| – | Team | VS | Opp Team |
| 1 | Mauldin (SC) | 6 – 5 | T.L. Hanna (SC) |
| 2 | Clover (SC) | 14 – 1 | Boiling Springs (SC) |
In the coming three days, these are the upcoming games in order of Best Game to Less-Best Game.
| – | Team | VS | Opp Team | Details |
| 1 | Wando (SC) | vs | Socastee (SC) | 3/15/2021 |
| 2 | Fort Mill (SC) | vs | Riverside (SC) | 3/16/2021 |
| 3 | Hilton Head (SC) | vs | Lucy Beckham (SC) | 3/15/2021 |
| 4 | Oceanside Collegiate Academy (SC) | vs | Porter-Gaud (SC) | 3/15/2021 |
| 5 | Mann (SC) | vs | Greenville (SC) | 3/15/2021 |
| 6 | Bishop England (SC) | vs | Philip Simmons (SC) | 3/15/2021 |
| 7 | Riverside (SC) | vs | T.L. Hanna (SC) | 3/17/2021 |
| 8 | Dutch Fork (SC) | vs | Lakeside (SC) | 3/15/2021 |
| 9 | Byrnes (SC) | vs | Wade Hampton (SC) | 3/17/2021 |
| 10 | Dorman (SC) | vs | Spartanburg (SC) | 3/16/2021 |
| 11 | Chapin (SC) | vs | Blythewood (SC) | 3/15/2021 |
| 12 | Christ Church Episcopal (SC) | vs | Boiling Springs (SC) | 3/16/2021 |
| 13 | May River (SC) | vs | Beaufort (SC) | 3/15/2021 |
| 14 | Mauldin (SC) | vs | Hillcrest (SC) | 3/15/2021 |
| 15 | White Knoll (SC) | vs | Lexington (SC) | 3/17/2021 |
| 16 | Irmo (SC) | vs | Nation Ford (SC) | 3/15/2021 |
