In order, based on the rankings of the two opponents, these were the “Best Games” and the game results. There was only one upset and it could hardly be called an upset: #23 (below) UMass-Lowell beat Hartford, 12-10.
| – | Team | VS | Opp Team | Details |
| 1 | Maryland | 19 – 12 | Rutgers | 3/13/2021 |
| 2 | Duke | 17 – 6 | Jacksonville | 3/14/2021 |
| 3 | Johns Hopkins | 13 – 6 | Penn State | 3/13/2021 |
| 4 | Syracuse | 17 – 9 | Stony Brook | 3/12/2021 |
| 5 | Lehigh | 18 – 6 | Bucknell | 3/14/2021 |
| 6 | Delaware | 19 – 12 | Drexel | 3/13/2021 |
| 7 | Villanova | 20 – 8 | St. John’s | 3/14/2021 |
| 8 | Vermont | 14 – 12 | UAlbany | 3/13/2021 |
| 9 | Ohio State | 13 – 10 | Michigan | 3/14/2021 |
| 10 | Robert Morris | 14 – 13 | Air Force | 3/13/2021 |
| 11 | Richmond | 23 – 6 | VMI | 3/13/2021 |
| 12 | Loyola | 16 – 6 | Lafayette | 3/13/2021 |
| 13 | LIU | 14 – 12 | Hobart | 3/13/2021 |
| 14 | UMass | 13 – 9 | Fairfield | 3/14/2021 |
| 15 | Boston University | 16 – 6 | Holy Cross | 3/12/2021 |
| 16 | Providence | 12 – 8 | Marquette | 3/13/2021 |
| 17 | Detroit Mercy | 11 – 7 | St. Bonaventure | 3/13/2021 |
| 18 | Monmouth | 7 – 6 | Siena | 3/13/2021 |
| 19 | Stony Brook | 13 – 4 | NJIT | 3/14/2021 |
| 20 | Manhattan | 10 – 7 | Canisius | 3/13/2021 |
| 21 | Cleveland State | 8 – 1 | Bellarmine | 3/13/2021 |
| 22 | Saint Joseph’s | 13 – 9 | Sacred Heart | 3/13/2021 |
| 23 | UMass Lowell | 12 – 10 | Hartford | 3/13/2021 |
| 24 | Merrimack | 11 – 5 | Wagner | 3/13/2021 |
In the next three days, these are the upcoming games in order of Best Game to Less-Best Game.
| – | Team | VS | Opp Team | Details |
| 1 | Denver | vs | Georgetown | 3/16/2021 |
| 2 | Notre Dame | vs | Marquette | 3/17/2021 |
| 3 | Fairfield | vs | Sacred Heart | 3/17/2021 |
