BOYS
| GA | 2/16/2021 | Brookwood (GA) | 15 | Dacula (GA) | 5 |
| GA | 2/16/2021 | Dunwoody (GA) | 8 | Marist (GA) | 4 |
| GA | 2/16/2021 | Greenbrier (GA) | 3 | Evans (GA) | 4 |
| NC | 2/16/2021 | Cardinal Gibbons (NC) | 18 | Enloe (NC) | 1 |
| NC | 2/16/2021 | Community School of Davidson (NC) | 4 | Lake Norman Charter (NC) | 14 |
| NC | 2/16/2021 | Fuquay – Varina (NC) | 22 | Terry Sanford (NC) | 1 |
| NC | 2/16/2021 | Garner Magnet (NC) | 3 | Apex Friendship (NC) | 16 |
| NC | 2/16/2021 | Holly Springs (NC) | 4 | Middle Creek (NC) | 14 |
| NC | 2/16/2021 | Lake Norman (NC) | 10 | Northwest Guilford (NC) | 6 |
| NC | 2/16/2021 | Marvin Ridge (NC) | 8 | Weddington (NC) | 7 |
| NC | 2/16/2021 | Mooresville (NC) | 8 | Providence (NC) | 19 |
| NC | 2/16/2021 | Myers Park (NC) | 12 | Ardrey Kell (NC) | 19 |
| NC | 2/16/2021 | Sanderson (NC) | 17 | Corinth Holders (NC) | 5 |
| NC | 2/16/2021 | South Garner (NC) | 1 | Pinecrest (NC) | 20 |
| NC | 2/16/2021 | South Iredell (NC) | 1 | Hough (NC) | 19 |
| SC | 2/16/2021 | Mauldin (SC) | 8 | Christ Church Episcopal (SC) | 10 |
GIRLS
| FL | 2/16/2021 | Calvary Christian (FL) | 12 | Palm Harbor University (FL) | 2 |
| FL | 2/16/2021 | Clearwater (FL) | 3 | Mitchell (FL) | 15 |
| FL | 2/16/2021 | Creekside (FL) | 5 | ESJ (FL) | 21 |
| FL | 2/16/2021 | Durant (FL) | 16 | Freedom (FL) | 3 |
| FL | 2/16/2021 | Estero (FL) | 10 | Golden Gate (FL) | 7 |
| FL | 2/16/2021 | Fort Myers (FL) | 0 | Naples (FL) | 18 |
| FL | 2/16/2021 | Lely (FL) | 17 | Palmetto Ridge (FL) | 2 |
| FL | 2/16/2021 | Oviedo (FL) | 2 | Bishop Moore (FL) | 15 |
| FL | 2/16/2021 | PSFAS (FL) | 18 | Lee (FL) | 1 |
| FL | 2/16/2021 | Riverdale (FL) | 2 | Cypress Lake (FL) | 20 |
| FL | 2/16/2021 | Seminole Ridge (FL) | 2 | Wellington (FL) | 18 |
| FL | 2/16/2021 | South Lake (FL) | 1 | Buchholz (FL) | 15 |
| FL | 2/16/2021 | St. Augustine (FL) | 23 | Eastside (SC) | 1 |
| FL | 2/16/2021 | Steinbrenner (FL) | 17 | Plant (FL) | 7 |
| FL | 2/16/2021 | Tampa Catholic (FL) | 10 | East Lake (FL) | 6 |
| FL | 2/16/2021 | Tohopekaliga (FL) | 10 | Jones (FL) | 4 |
| FL | 2/16/2021 | Trinity Prep (FL) | 14 | Olympia (FL) | 5 |
| FL | 2/16/2021 | West Boca Raton (FL) | 0 | Boca Raton (FL) | 19 |
| FL | 2/16/2021 | West Broward (FL) | 2 | Taravella (FL) | 13 |
| FL | 2/16/2021 | Wiregrass Ranch (FL) | 20 | Pasco (FL) | 2 |
| GA | 2/16/2021 | North Paulding (GA) | 20 | Parkview (GA) | 4 |
| GA | 2/16/2021 | Pace Academy (GA) | 2 | Fellowship Christian (GA) | 17 |
| NC | 2/16/2021 | Ardrey Kell (NC) | 1 | Myers Park (NC) | 19 |
| NC | 2/16/2021 | David W. Butler (NC) | 7 | Independence (NC) | 16 |
| NC | 2/16/2021 | E.A. Laney (NC) | 17 | New Hanover (NC) | 1 |
| NC | 2/16/2021 | Enloe (NC) | 0 | Cardinal Gibbons (NC) | 19 |
| NC | 2/16/2021 | Glenn (NC) | 0 | West Forsyth (NC) | 15 |
| NC | 2/16/2021 | Lake Norman Charter (NC) | 16 | Mooresville (NC) | 5 |
| NC | 2/16/2021 | Watauga (NC) | 1 | Asheville (NC) | 6 |
